Efficacy and tolerability of eslicarbazepine acetate as monotherapy in patients of newly diagnosed focal epilepsy
نویسندگان
چکیده
Introduction Eslicarbazepine Acetate, a novel anti-epileptic drug has been approved as monotherapy in focal onset seizures, with/without secondary generalization adults. many advantages over older drugs and is useful patients of new epilepsy. Objectives Aim our study was to determine the efficacy safety observe its well-tolerated use monitor adverse effects newly diagnosed Methods Study done at Department Psychiatry, Teerthanker Mahaveer University, Moradabad. A total 30 cases epilepsy between 18-60 years age were studied for 6 months, using Semi-structured Interview Liverpool Adverse Events Profile. Results Majority males (58%), 21-30 years. Patients with partial/focal seizures (63%) more common than those generalized (37%). participants had 1-2 episodes weekly(48%), while some almost daily(32%). on Acetate 800 mg two divided doses daily (64%), others received 1200 three doses(32%). The mean Profile score initially 28.34 ± 6.28 which significantly improved after 4 weeks treatment 22.80 4.35 (p < 0.05). improvement other No major side observed. Conclusions effective treating Better results this are found patients. Disclosure significant relationships.
منابع مشابه
Levetiracetam monotherapy for newly diagnosed epilepsy patients
We retrospectively reviewed the charts of all of our patients with a history of partial seizures, with and without secondarily generalisation, who received levetiracetam (LEV; Keppra) for treatment of their seizures during the years 2000-2002. Forty-five patients were identified, 13 of whom began LEV as first line therapy. Eleven patients continued on LEV for at least 6 months; six of whom beca...
متن کاملEfficacy and tolerability of brivaracetam compared to lacosamide, eslicarbazepine acetate, and perampanel as adjunctive treatments in uncontrolled focal epilepsy: Results of an indirect comparison meta-analysis of RCTs
BACKGROUND Brivaracetam (BRV), eslicarbazepine acetate (ESL), lacosamide (LCM), and perampanel (PER) have been recently marketed as adjunctive treatments for focal onset seizures. To date, no randomized controlled trial (RCT) has directly compared BRV with ESL, LCM, or PER. PURPOSE To compare BRV with the other add-on AEDs in patients with uncontrolled focal epilepsy, estimating their efficac...
متن کاملEfficacy and tolerability of the first antiepileptic drug in children with newly diagnosed idiopathic epilepsy
PURPOSE Limited data are available for the effectiveness of the antiepileptic drugs in children in daily clinical practice. The aim of this study was to investigate the efficacy and tolerability of the first prescribed old and new antiepileptic drugs in children with newly diagnosed idiopathic epilepsy during a 12-month period. METHOD A total of 289 children (141 females and 148 males) who re...
متن کاملEslicarbazepine Acetate: A New Improvement on a Classic Drug Family for the Treatment of Partial-Onset Seizures
Eslicarbazepine acetate is a new anti-epileptic drug belonging to the dibenzazepine carboxamide family that is currently approved as adjunctive therapy and monotherapy for partial-onset (focal) seizures. The drug enhances slow inactivation of voltage-gated sodium channels and subsequently reduces the activity of rapidly firing neurons. Eslicarbazepine acetate has few, but some, drug-drug intera...
متن کاملTime-to-Seizure Modeling of Lacosamide Used in Monotherapy in Patients with Newly Diagnosed Epilepsy
OBJECTIVES To quantify the relationship between exposure to lacosamide monotherapy and seizure probability, and to simulate the effect of changing the dose regimen. METHODS Structural time-to-event models for dropouts (not because of a lack of efficacy) and seizures were developed using data from 883 adult patients newly diagnosed with epilepsy and experiencing focal or generalized tonic-clon...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Psychiatry
سال: 2021
ISSN: ['0924-9338', '1778-3585']
DOI: https://doi.org/10.1192/j.eurpsy.2021.2049